GlcNAcylation Plays an Essential Role in Breast Cancer Metastasis
نویسندگان
چکیده
منابع مشابه
GlcNAcylation plays an essential role in breast cancer metastasis.
GlcNAcylation, a dynamic posttranslational modification, is involved in a wide range of biological processes and some human diseases. Although there is emerging evidence that some tumor-associated proteins are modified by GlcNAcylation, the role of GlcNAcylation in tumor progression remains unclear. Here, we show that GlcNAcylation enhances the migration/invasion of breast cancer cells in vitro...
متن کاملTrkC plays an essential role in breast tumor growth and metastasis.
Tropomyosin-related kinase (Trk) C, a member of the Trk family of neurotrophin receptors, has been implicated in the growth and survival of human cancer tissues. Here, we report that TrkC is frequently overexpressed in human breast cancers and plays an essential role in tumor growth and metastasis. Ectopic expression of TrkC in non-malignant mammary epithelial cells suppressed anoikis, which co...
متن کاملTAB3 O-GlcNAcylation promotes metastasis of triple negative breast cancer
O-GlcNAcylation is a post-translational modification that regulates a broad range of nuclear and cytoplasmic proteins and is emerging as a key regulator of various biological processes. Although previous studies have shown that increased levels of global O-GlcNAcylation and O-GlcNActransferase are linked to the incidence of metastasis in triple negative breast cancer (TNBC) patients, the molecu...
متن کاملVisfatin: an adipokine that plays a crucial role in increasing the risk of cancer
Obesity is an important public health problem worldwide. Epidemiological studies have demonstrated that obesity is associated with an increased risk of several cancer types. Also, obesity is associated with an increase in cancer mortality. Biological mechanisms and the relationship between obesity and cancer are complex and not well understood. Studies on the role of adiposederived factors in c...
متن کاملTwist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
Metastasis is a multistep process during which cancer cells disseminate from the site of primary tumors and establish secondary tumors in distant organs. In a search for key regulators of metastasis in a murine breast tumor model, we have found that the transcription factor Twist, a master regulator of embryonic morphogenesis, plays an essential role in metastasis. Suppression of Twist expressi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Research
سال: 2010
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-09-1887